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Glossary term

Treatment-resistant depression (TRD)

Depression that has not responded to at least 2 adequate trials of antidepressants from different classes. The primary indication for ketamine therapy.

Which Procedures Involve Treatment-resistant depression?

Treatment-resistant depression (TRD) appears in the following procedure guides on ProcedureFinder:

Frequently Asked Questions

What is Treatment-resistant depression? +

Depression that has not responded to at least 2 adequate trials of antidepressants from different classes. The primary indication for ketamine therapy. On ProcedureFinder, Treatment-resistant depression (TRD) appears in the Ketamine Infusion Therapy cost guide. IV ketamine has substantial published evidence for rapid antidepressant effects in treatment-resistant depression, including multiple RCTs showing 60-70% response rates and 30-40% remission rates after a single infusion.

How much does ketamine infusion therapy cost? +

Ketamine Infusion Therapy costs $350 to $850 per infusion (induction series typically 6 infusions) nationally, with a median of $525 in ProcedureFinder's cash-pay benchmarks. IV ketamine infusion series for treatment-resistant depression, PTSD, and chronic pain. Standard induction protocol is six infusions over 2-3 weeks.

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